Father 4 negative mother 1 positive. "negative" future mothers, Rh factor, Rh conflict

Today I went to get the test results for my blood group and Rh factor, I have 3, positive! This is good, because there will be no conflicts!!! (My husband has 4 positive)))

Inheritance of blood groups

Parents with the first blood group can only have a child with the first group.

Parents with the second have a child with the first or second.

However, during pregnancy, under certain circumstances, but also spontaneously, a small amount of the baby's blood can pass into maternal circulation. When the baby's red blood cells return to the mother's body, they are recognized by the defense system. If the baby's red blood cells carry blood type antigens that are different from those of the mother, this system may react by creating antibodies to the baby's red blood cells.

Blood groups are grouped into systems. They aim to demonstrate antigens present on red blood cells and antibodies in plasma. If so, these are antibodies acquired after a transfusion or pregnancy. On the other hand, during subsequent pregnancies, antibodies are present from the very beginning. Consequences of immunization against RDR on an Rh-positive child.

Tropical spastic paraparesis. Tropical spastic paraparesis is characterized by spastic paraplegia of installation and progressive development without convulsions or remissions. This condition is common in adults in general after 40 years of age. It should be noted that cases of more rapid development have been described, particularly after transfusion infection. The risk of developing this pathology is less than 1%.

It is likely that there is interference from an immunological mechanism in this condition. Prevalence in these endemic areas increases with age, probably through a cohort effect, and is higher in women, presumably because sexual transmission is more common between men and women. The virus emerged from these initial foci to spread to other geographic areas.

Parents with the third have a child with the first or third.

Parents with the first and second have a child with the first or second.

Parents with the first and third have a child with the first or third.

Parents with the second and third have a child with any blood group.

Parents with the first and fourth have a child with the second and third.

Parents with the second and fourth have a child with the second, third and fourth

Anemia in a child can occur at birth or in cases of significant immunization from intrauterine life. After birth, the breakdown of red blood cells continues and releases bilirubin, a yellow pigment that causes jaundice, or jaundice, in the baby. In severe forms, bilirubin is produced in large quantities and accumulates quickly; it can become toxic to a child's brain if left untreated.

All these manifestations correspond hemolytic disease newborn The search for irregular agglutinins provides follow-up. This treatment is offered to pregnant women during pregnancy and at birth because this is the time when an important percentage of the baby's red blood cells are often found in maternal circulation. This is a regulated product that is ordered from a pharmacy and will be administered 48 hours after looking for irregular agglutinins. If you've just found out you're pregnant, one of the first and most important tests you'll need to do is a blood test to find out what your blood type is.

In Europe, their prevalence in the general population is very low. Methods of infection are carried out by blood, sexually or vertically. This type of contamination is associated with blood transfusions, the use of contaminated syringes or equipment by drug addicts, and plasma and its derivatives do not contaminate. the number of lymphocytes decreases over time. There was an 87% risk of transmission when the derivative was stored for less than 4 days and no more than 14 days. The risk of blood poisoning is now extremely low: one in every 5 million donations.

This is more in the sense of man-woman than in the sense of woman-man. An associated pathology is tropical spastic paraparesis. The risk of seropositivity of children is zero for positive negative pairs of fathers and mothers and 20% for negative mother pairs with positive father. Transfer is mainly carried out by breastfeeding and depends on maternal viremia and duration of breastfeeding. A related pathology is T-cell leukemia. They are rare in cases of intrauterine or perinatal transmission.

Parents with third and fourth- a child with the second, third and fourth.

Parents with the fourth have a child with the second, third and fourth.

If one of the parents has the first blood group, the child cannot have the fourth. And vice versa - if one of the parents has a fourth, the child cannot have a first.

Antigen B matures by the age of one year, so it is sometimes not detected at birth. As a result, a child with the third blood group may receive the first blood group at birth, and a child with the fourth may receive the second. By the age of one year, the antigen matures and the blood type “changes.”

This basic test determines both your blood type and your Rh factor. Your Rh factor can play an important role in your baby's health. This is why it is important to have this information from the beginning of your pregnancy. Each person has specific proteins for their blood type on the surface of their red blood cells.

If you carry this protein, your blood will be Rh positive. Most people are Rh positive. But if an Rh negative woman and an Rh positive man conceive a child, there is a chance that your baby may have health problems. Approximately half of the children of an Rh-negative mother and an Rh-positive father are Rh-positive. However, during childbirth, the mother's blood and the baby's blood may be mixed.

These delicate techniques are the responsibility of a highly specialized laboratory. As with other retroviruses, antibody carriers carry the virus, which persists throughout life. Depending on the proviral load, the intensity of the antibody response will be more or less strong, as will the number of abnormal lymphocytes. Serological diagnosis is based on screening, confirmation and differentiation of two serotypes.

Table 1 lists the reagents registered with the Medicines Agency. Given that screening reagents may produce false-positive signals, any serum producing a signal greater than or equal to the threshold should be confirmed. Confirmation essentially requires Western blotting. Two Western blots are prepared from a purified viral lysate enriched for the transmembrane recombinant glycoprotein common to both viruses. Sometimes positivity is weaker or even a gray area.

Group incompatibility:

During pregnancy, not only Rh conflict (cm) can occur, but also blood group conflict. If the mother has the first blood group, and the child has any other, she can produce antibodies against it: antiA, antiB. It is necessary to check the presence of group antibodies in women with the first blood group, and in the presence of immune antibodies, warn pediatricians about the possible development of hemolytic disease of the newborn based on blood group.

This can cause the baby's red blood cells to dilate and rupture. The first injection is given around the twenty-eighth week of pregnancy, and the second is given in the first 72 hours of the newborn's life. In exceptional cases, if the incompatibility is severe and the baby is at risk, a series of special blood transfusions called exchange transfusions may be performed while the baby is still in the womb or after birth. Exchange transfusions give blood to a baby whose red blood cells are Rh negative.

In extreme cases, when the number of red blood cells destroyed is very high, it can even lead to fetal death. If you don't know what your Rh factor is and you think you might be pregnant, it's important that you start regular prenatal consultations as soon as possible.

In case of two positive tests, the Western blot should be continued. Samples with low signal intensity should be distrustful in the absence of other responses that may correspond to false positives. The possibility of seroconversion will be discarded if the profile has not developed after two months. Table 2 provides criteria for interpreting Western blots.

Chemotherapy treatment for adult T-cell leukemias is very disappointing. Treatment of myelopathy with corticosteroids provides only temporary benefit. Due to the relative stability of the genomic sequences encoding envelope proteins, they may be good vaccine candidates because they induce the synthesis of neutralizing antibodies.

Rh factor

Protein on the membrane of red blood cells. Present in 85% of Rh-positive people. The remaining 15% are Rh negative.

Inheritance: R - Rh factor gene. r - absence of Rh factor.

Parents are Rh positive (RR, Rr) - the child can be Rh positive (RR, Rr) or Rh negative (rr).

One parent is Rh positive (RR, Rr), the other is Rh negative (rr) - the child can be Rh positive (Rr) or Rh negative (rr).

Expression of gratitude. The author warmly thanks Jean-Marie Lemaire for providing him with photographic documents of various Western blots. Your child needs attention: did you answer negatively or positively? Your child is eager to capture your gaze and appreciates your presence to share his discoveries and show you his exploits. Your attention feeds your self-esteem. Attention, whether positive or negative, therefore affects your child's behavior.

In fact, your child builds the image he has in the eyes of adults and the attention they give him. If you give your child attention only to emphasize that he is not doing well, he may perceive himself as less competent or unable to do things right. On the contrary, if you emphasize his good steps, he will develop a sense of competence and he will feel loved and valued. You will notice, for example, that after spending time with you, your baby will stop extending his bedtime to get your attention.

The parents are Rh negative, the child can only be Rh negative.

The Rh factor, like the blood group, must be taken into account when receiving blood transfusions. When the Rh factor enters the blood of a Rh-negative person, anti-Rh antibodies are formed to it, which glue Rh-positive red blood cells into coin columns.

Additionally, if you pay attention to the behavior, you will increase the likelihood that it will happen again. Therefore, it is important to choose the behavior you want to encourage. Learn to recognize small positive actions that your child does naturally but is rarely emphasized because they don't bother you.

Aggression or need for attention?

There are several ways to give positive attention. For example, you can congratulate your baby for grasping an object with his hand or for successfully making small noises with his rattle. Make a smile, a wink, a congratulations, a hand sign, a clap, or any other sign that agrees with him. In particular, describe your child's actions and satisfaction. For example, you could say: Okay, you shared your bun with your sister. Look how happy she is. Around 4 or 5 years old, you can encourage your child to encourage his or her good behavior. This type of “congratulations” will also help her learn to recognize her negative gestures. In your moments with your child, highlight the fun that you have to change and play with him. These moments will give your little one the motivation to reproduce positive gestures.

  • Very early on, children respond to positive attention.
  • Even small gestures can be meaningful to your child.
  • These gestures must be immediate and specific.
Some children may develop aggressive behavior to get the attention of adults around them.

Rhesus conflict

It can occur during the pregnancy of an Rh-negative woman with a Rh-positive fetus (Rh factor from the father). When fetal red blood cells enter the mother's bloodstream, anti-Rh antibodies are formed against the Rh factor. Normally, the blood flow of mother and fetus mixes only during childbirth, so Rh-conflict is theoretically possible in the second and subsequent pregnancies with an Rh-positive fetus. In practice, in modern conditions, there is often an increase in the permeability of blood vessels of the placenta, various pathologies of pregnancy, leading to the entry of fetal red blood cells into the mother’s blood during the first pregnancy. Anti-Rhesus antibodies can also form not only during pregnancy, but also through contact with Rh positive blood. Therefore, anti-Rh antibodies must be determined during any pregnancy in an Rh-negative woman starting from 8 weeks (the time of formation of the Rh factor in the fetus). To prevent their formation, carry out prevention of Rhesus conflict. All Rh-negative women who do not have antibodies to the Rh factor at 28 weeks of pregnancy are given anti-Rhesus immunoglobulin at a dose of 350 mcg. And another dose is given within 72 hours after birth. Immunoglobulin is also administered after any end of pregnancy of more than 8 weeks (miscarriage, abortion, anembryonia, frozen pregnancy, premature birth) and during the amniocentesis procedure. During pregnancy, it is possible to use only imported immunoglobulin preparations, in particular, Bay-RoDee. After pregnancy, it is possible to use domestic immunoglobulin, which is better than nothing, but worse than an imported drug standardized in terms of the dose of antibodies.

For example, by pushing a classmate or removing a toy from your sister's hands, your child may know that you or her teacher will come to talk to her. If your child behaves in a similar way, you should help him understand that there is best ways attract the attention of adults.

Express your disagreement clearly, but avoid long sermons that speak negatively to the child. If you ignore an objectionable gesture, your baby may stop the behavior, but he will continue to make disturbing gestures to feel validated. Even if it doesn't merit positive attention, your child needs to know that you still value them. Expect an increase in aggressive actions at the start of these measures. The child may try to test his limits. Pay attention to your child when he behaves well. Don't wait for him to make a mistake to pay attention. You give it constant and regular attention.

  • Avoid deliberately ignoring aggressive behavior.
  • Through your gestures, your child expresses a need that needs to be addressed.
Short blood circulation of mother and child are well separated.


Today I went to get the test results for my blood group and Rh factor, I have 3, positive! This is good, because there will be no conflicts!!! (My husband has 4 positive)))

Inheritance of blood groups

Parents with the first blood group can only have a child with the first group.

Parents with the second have a child with the first or second.

However, during pregnancy, under certain circumstances, but also spontaneously, a small amount of the baby's blood can pass into maternal circulation. When the baby's red blood cells return to the mother's body, they are recognized by the defense system. If the baby's red blood cells carry blood type antigens that are different from those of the mother, this system may react by creating antibodies to the baby's red blood cells.

Blood groups are grouped into systems. They aim to demonstrate antigens present on red blood cells and antibodies in plasma. If so, these are antibodies acquired after a transfusion or pregnancy. On the other hand, during subsequent pregnancies, antibodies are present from the very beginning. Consequences of immunization against RDR on an Rh-positive child.

Tropical spastic paraparesis. Tropical spastic paraparesis is characterized by spastic paraplegia of installation and progressive development without convulsions or remissions. This condition is common in adults in general after 40 years of age. It should be noted that cases of more rapid development have been described, particularly after transfusion infection. The risk of developing this pathology is less than 1%.

It is likely that there is interference from an immunological mechanism in this condition. Prevalence in these endemic areas increases with age, probably through a cohort effect, and is higher in women, presumably because sexual transmission is more common between men and women. The virus emerged from these initial foci to spread to other geographic areas.

Parents with the third have a child with the first or third.

Parents with the first and second have a child with the first or second.

Parents with the first and third have a child with the first or third.

Parents with the second and third have a child with any blood group.

Parents with the first and fourth have a child with the second and third.

Parents with the second and fourth have a child with the second, third and fourth

Anemia in a child can occur at birth or in cases of significant immunization from intrauterine life. After birth, the breakdown of red blood cells continues and releases bilirubin, a yellow pigment that causes jaundice, or jaundice, in the baby. In severe forms, bilirubin is produced in large quantities and accumulates quickly; it can become toxic to a child's brain if left untreated.

All these manifestations correspond to hemolytic disease of the newborn. The search for irregular agglutinins provides follow-up. This treatment is offered to pregnant women during pregnancy and at birth because this is the time when an important percentage of the baby's red blood cells are often found in maternal circulation. This is a regulated product that is ordered from a pharmacy and will be administered 48 hours after looking for irregular agglutinins. If you've just found out you're pregnant, one of the first and most important tests you'll need to do is a blood test to find out what your blood type is.

In Europe, their prevalence in the general population is very low. Methods of infection are carried out by blood, sexually or vertically. This type of contamination is associated with blood transfusions, the use of contaminated syringes or equipment by drug addicts, and plasma and its derivatives do not contaminate. the number of lymphocytes decreases over time. There was an 87% risk of transmission when the derivative was stored for less than 4 days and no more than 14 days. The risk of blood poisoning is now extremely low: one in every 5 million donations.

This is more in the sense of man-woman than in the sense of woman-man. An associated pathology is tropical spastic paraparesis. The risk of child seropositivity is zero for positive-negative pairs of fathers and mothers and 20% for negative-mother pairs with a positive father. Transmission is primarily through breastfeeding and is dependent on maternal viremia and duration of breastfeeding. A related pathology is T-cell leukemia. They are rare in cases of intrauterine or perinatal transmission.

Parents with third and fourth- a child with the second, third and fourth.

Parents with the fourth have a child with the second, third and fourth.

If one of the parents has the first blood group, the child cannot have the fourth. And vice versa - if one of the parents has a fourth, the child cannot have a first.

Antigen B matures by the age of one year, so it is sometimes not detected at birth. As a result, a child with the third blood group may receive the first blood group at birth, and a child with the fourth may receive the second. By the age of one year, the antigen matures and the blood type “changes.”

This basic test determines both your blood type and your Rh factor. Your Rh factor can play an important role in your baby's health. This is why it is important to have this information from the beginning of your pregnancy. Each person has specific proteins for their blood type on the surface of their red blood cells.

If you carry this protein, your blood will be Rh positive. Most people are Rh positive. But if an Rh negative woman and an Rh positive man conceive a child, there is a chance that your baby may have health problems. Approximately half of the children of an Rh-negative mother and an Rh-positive father are Rh-positive. However, during childbirth, the mother's blood and the baby's blood may be mixed.

These delicate techniques are the responsibility of a highly specialized laboratory. As with other retroviruses, antibody carriers carry the virus, which persists throughout life. Depending on the proviral load, the intensity of the antibody response will be more or less strong, as will the number of abnormal lymphocytes. Serological diagnosis is based on screening, confirmation and differentiation of two serotypes.

Table 1 lists the reagents registered with the Medicines Agency. Given that screening reagents may produce false-positive signals, any serum producing a signal greater than or equal to the threshold should be confirmed. Confirmation essentially requires Western blotting. Two Western blots are prepared from a purified viral lysate enriched for the transmembrane recombinant glycoprotein common to both viruses. Sometimes positivity is weaker or even a gray area.

Group incompatibility:

During pregnancy, not only Rh conflict (cm) can occur, but also blood group conflict. If the mother has the first blood group, and the child has any other, she can produce antibodies against it: antiA, antiB. It is necessary to check the presence of group antibodies in women with the first blood group, and in the presence of immune antibodies, warn pediatricians about the possible development of hemolytic disease of the newborn based on blood group.

This can cause the baby's red blood cells to dilate and rupture. The first injection is given around the twenty-eighth week of pregnancy, and the second is given in the first 72 hours of the newborn's life. In exceptional cases, if the incompatibility is severe and the baby is at risk, a series of special blood transfusions called exchange transfusions may be performed while the baby is still in the womb or after birth. Exchange transfusions give blood to a baby whose red blood cells are Rh negative.

In extreme cases, when the number of red blood cells destroyed is very high, it can even lead to fetal death. If you don't know what your Rh factor is and you think you might be pregnant, it's important that you start regular prenatal consultations as soon as possible.

In case of two positive tests, the Western blot should be continued. Samples with low signal intensity should be distrustful in the absence of other responses that may correspond to false positives. The possibility of seroconversion will be discarded if the profile has not developed after two months. Table 2 provides criteria for interpreting Western blots.

Chemotherapy treatment for adult T-cell leukemias is very disappointing. Treatment of myelopathy with corticosteroids provides only temporary benefit. Due to the relative stability of the genomic sequences encoding envelope proteins, they may be good vaccine candidates because they induce the synthesis of neutralizing antibodies.

Rh factor

Protein on the membrane of red blood cells. Present in 85% of Rh-positive people. The remaining 15% are Rh negative.

Inheritance: R - Rh factor gene. r - absence of Rh factor.

Parents are Rh positive (RR, Rr) - the child can be Rh positive (RR, Rr) or Rh negative (rr).

One parent is Rh positive (RR, Rr), the other is Rh negative (rr) - the child can be Rh positive (Rr) or Rh negative (rr).

Expression of gratitude. The author warmly thanks Jean-Marie Lemaire for providing him with photographic documents of various Western blots. Your child needs attention: did you answer negatively or positively? Your child is eager to capture your gaze and appreciates your presence to share his discoveries and show you his exploits. Your attention feeds your self-esteem. Attention, whether positive or negative, therefore affects your child's behavior.

In fact, your child builds the image he has in the eyes of adults and the attention they give him. If you give your child attention only to emphasize that he is not doing well, he may perceive himself as less competent or unable to do things right. On the contrary, if you emphasize his good steps, he will develop a sense of competence and he will feel loved and valued. You will notice, for example, that after spending time with you, your baby will stop extending his bedtime to get your attention.

The parents are Rh negative, the child can only be Rh negative.

The Rh factor, like the blood group, must be taken into account when receiving blood transfusions. When the Rh factor enters the blood of a Rh-negative person, anti-Rh antibodies are formed to it, which glue Rh-positive red blood cells into coin columns.

Additionally, if you pay attention to the behavior, you will increase the likelihood that it will happen again. Therefore, it is important to choose the behavior you want to encourage. Learn to recognize small positive actions that your child does naturally but is rarely emphasized because they don't bother you.

Aggression or need for attention?

There are several ways to give positive attention. For example, you can congratulate your baby for grasping an object with his hand or for successfully making small noises with his rattle. Make a smile, a wink, a congratulations, a hand sign, a clap, or any other sign that agrees with him. In particular, describe your child's actions and satisfaction. For example, you could say: Okay, you shared your bun with your sister. Look how happy she is. Around 4 or 5 years old, you can encourage your child to encourage his or her good behavior. This type of “congratulations” will also help her learn to recognize her negative gestures. In your moments with your child, highlight the fun that you have to change and play with him. These moments will give your little one the motivation to reproduce positive gestures.

  • Very early on, children respond to positive attention.
  • Even small gestures can be meaningful to your child.
  • These gestures must be immediate and specific.
Some children may develop aggressive behavior to get the attention of adults around them.

Rhesus conflict

It can occur during the pregnancy of an Rh-negative woman with a Rh-positive fetus (Rh factor from the father). When fetal red blood cells enter the mother's bloodstream, anti-Rh antibodies are formed against the Rh factor. Normally, the blood flow of mother and fetus mixes only during childbirth, so Rh-conflict is theoretically possible in the second and subsequent pregnancies with an Rh-positive fetus. In practice, in modern conditions, there is often an increase in the permeability of blood vessels of the placenta, various pathologies of pregnancy, leading to the entry of fetal red blood cells into the mother’s blood during the first pregnancy. Anti-Rh antibodies can also be formed not only during pregnancy, but also through contact with Rh-positive blood. Therefore, anti-Rh antibodies must be determined during any pregnancy in an Rh-negative woman starting from 8 weeks (the time of formation of the Rh factor in the fetus). To prevent their formation, carry out prevention of Rhesus conflict. All Rh-negative women who do not have antibodies to the Rh factor at 28 weeks of pregnancy are given anti-Rhesus immunoglobulin in a dose of 350 mcg in the interval between 28 and 34 weeks of pregnancy. And another dose is given within 72 hours after birth. Immunoglobulin is also administered after any end of pregnancy of more than 8 weeks (miscarriage, abortion, anembryonia, frozen pregnancy, premature birth) and during the amniocentesis procedure. During pregnancy, it is possible to use only imported immunoglobulin preparations, in particular, Bay-RoDee. After pregnancy, it is possible to use domestic immunoglobulin, which is better than nothing, but worse than an imported drug standardized in terms of the dose of antibodies.

For example, by pushing a classmate or removing a toy from your sister's hands, your child may know that you or her teacher will come to talk to her. If your child behaves in a similar way, you should help him understand that there are better ways to get adults' attention.

Express your disagreement clearly, but avoid long sermons that speak negatively to the child. If you ignore an objectionable gesture, your baby may stop the behavior, but he will continue to make disturbing gestures to feel validated. Even if it doesn't merit positive attention, your child needs to know that you still value them. Expect an increase in aggressive actions at the start of these measures. The child may try to test his limits. Pay attention to your child when he behaves well. Don't wait for him to make a mistake to pay attention. You give it constant and regular attention.

  • Avoid deliberately ignoring aggressive behavior.
  • Through your gestures, your child expresses a need that needs to be addressed.
Short blood circulation of mother and child are well separated.